TargetMol

Nutlin-3

Product Code:
 
TAR-T2158
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2158-2mg2mg£114.00
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TAR-T2158-5mg5mg£136.00
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TAR-T2158-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T2158-10mg10mg£172.00
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TAR-T2158-25mg25mg£280.00
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TAR-T2158-50mg50mg£457.00
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TAR-T2158-100mg100mg£490.00
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This product comes from: United States.
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Further Information

Bioactivity:
Nutlin-3 is an MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
CAS:
548472-68-0
Formula:
C30H30Cl2N4O4
Molecular Weight:
581.49
Pathway:
Ubiquitination
Purity:
0.9989
SMILES:
COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Target:
E1/E2/E3 Enzyme

References

1. Yu Z, et al. Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. Int J Mol Sci. 2014 Sep 5;15(9):15741-53. 2. Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.Cancer Biol Ther. Cancer Biol Ther. 2012 Aug;13(10):915-24. 3. Supiot S, et al. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53. Mol Cancer Ther. 2008 Apr;7(4):993-9.