TargetMol

BIX-01294 trihydrochloride

Product Code:
 
TAR-T1959
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1959-1mg1mg£100.00
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TAR-T1959-2mg2mg£111.00
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TAR-T1959-5mg5mg£123.00
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TAR-T1959-10mg10mg£158.00
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TAR-T1959-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T1959-25mg25mg£233.00
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TAR-T1959-50mg50mg£302.00
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TAR-T1959-100mg100mg£487.00
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TAR-T1959-500mg500mg£1,002.00
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Further Information

Bioactivity:
BIX01294 is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.
CAS:
1392399-03-9
Formula:
C28H41Cl3N6O2
Molecular Weight:
600.03
Pathway:
Autophagy; Chromatin/Epigenetic
Purity:
0.9995
SMILES:
Cl.Cl.Cl.COc1cc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC)N1CCCN(C)CC1
Target:
Histone Methyltransferase; Autophagy

References

1. Kubicek S, et al. Mol Cell, 2007, 25(3), 473-481. 2. Imai K, et al. J Biol Chem, 2010, 285(22), 16538-16545. 3. Zhang W, Yang D, Yuan Y, et al. Muscular G9a regulates muscle-liver-fat axis by musclin under overnutrition in female mice[J]. Diabetes. 2020 4. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2019: 1-16. 5. Liu Shanshan, Yu Sun, Ming Jiang, Yangkai Li, Ye Tian, Weili Xue, Ninghe Ding, Zheng Ling, et al. Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase [J]. Hepatology. 2017 Aug;66(2):631-645