TargetMol

Lenalidomide-Br

Product Code:
 
TAR-T18064
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T18064-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T18064-100mg100mg£111.00
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Further Information

Bioactivity:
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36.
CAS:
2093387-36-9
Formula:
C13H11BrN2O3
Molecular Weight:
323.146
Pathway:
PROTAC
Purity:
0.9837
SMILES:
Brc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
Target:
Ligand for E3 Ligase

References

1. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. 2. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.