TargetMol

SBI-425

Product Code:
 
TAR-T16859
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16859-1mg1mg£95.00
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TAR-T16859-5mg5mg£128.00
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TAR-T16859-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T16859-10mg10mg£166.00
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TAR-T16859-25mg25mg£225.00
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TAR-T16859-50mg50mg£295.00
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TAR-T16859-100mg100mg£404.00
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This product comes from: United States.
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Further Information

Bioactivity:
SBI-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP). SBI-425 effectively inhibits TNAP in the vasculature and improves cardiovascular parameters and survival without a detectable change in the bone.
CAS:
1451272-71-1
Formula:
C13H12ClN3O4S
Molecular Weight:
341.77
Purity:
0.9936
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)C(N)=O

References

1. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. 2. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.