TargetMol

Mardepodect hydrochloride (898562-94-2 free base)

Product Code:
 
TAR-T16498
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16498-100mg100mgEnquire
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TAR-T16498-200mg200mgEnquire
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TAR-T16498-2mg2mg£161.00
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TAR-T16498-5mg5mg£208.00
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TAR-T16498-1mL1 mL * 10 mM (in DMSO)£220.00
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TAR-T16498-10mg10mg£278.00
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TAR-T16498-50mg50mg£631.00
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Further Information

Bioactivity:
Mardepodect hydrochloride can cross the blood-brain barrier. Mardepodect hydrochloride is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). It has >1000-fold selectivity over other PDEs.
CAS:
T16498
Formula:
C25H21ClN4O
Molecular Weight:
428.91
Pathway:
Metabolism
Purity:
0.98
SMILES:
CN1N=C(C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C(C5=CC=NC=C5)=C1.Cl[H]
Target:
PDE

References

1. Wilson JM et al. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. 2015 Dec;99:379-86. 2. Verhoest PR et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem. 2009 Aug 27;52(16):5188-96.