TargetMol

PBIT

Product Code:
 
TAR-T16435
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16435-1mg1mg£98.00
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TAR-T16435-2mg2mg£109.00
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TAR-T16435-5mg5mg£135.00
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TAR-T16435-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T16435-10mg10mg£173.00
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TAR-T16435-25mg25mg£302.00
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TAR-T16435-50mg50mg£454.00
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TAR-T16435-100mg100mg£624.00
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Further Information

Bioactivity:
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
CAS:
2514-30-9
Formula:
C14H11NOS
Molecular Weight:
241.31
Pathway:
Chromatin/Epigenetic
Purity:
0.9995
SMILES:
Cc1ccc(cc1)-n1sc2ccccc2c1=O
Target:
Histone Demethylase; Histone Methyltransferase

References

1. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.