TargetMol

GNE 2861

Product Code:
 
TAR-T16429
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16429-1mg1mg£99.00
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TAR-T16429-2mg2mg£111.00
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TAR-T16429-5mg5mg£134.00
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TAR-T16429-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T16429-10mg10mg£177.00
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TAR-T16429-25mg25mg£289.00
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TAR-T16429-50mg50mg£436.00
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TAR-T16429-100mg100mg£610.00
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Further Information

Bioactivity:
GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.
CAS:
1394121-05-1
Formula:
C22H26N6O2
Molecular Weight:
406.49
Pathway:
Cytoskeletal Signaling
Purity:
0.9907
SMILES:
COCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC1(O)CCCCC1
Target:
PAK

References

1. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.