TargetMol

OSMI-1

Product Code:
 
TAR-T16409
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16409-1mg1mg£98.00
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TAR-T16409-2mg2mg£109.00
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TAR-T16409-5mg5mg£132.00
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TAR-T16409-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T16409-10mg10mg£172.00
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TAR-T16409-25mg25mg£237.00
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TAR-T16409-50mg50mg£367.00
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TAR-T16409-100mg100mg£511.00
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Further Information

Bioactivity:
OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor (IC50: 2.7 μM).
CAS:
1681056-61-0
Formula:
C28H25N3O6S2
Molecular Weight:
563.64
Pathway:
Metabolism;
Purity:
0.9679
SMILES:
COc1ccccc1[C@@H](NS(=O)(=O)c1ccc2[nH]c(=O)ccc2c1)C(=O)N(Cc1ccco1)Cc1cccs1
Target:
Acyltransferase

References

1. Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. 2. Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.