TargetMol

AZD5582 acetate (1258392-53-8 free base)

Product Code:
 
TAR-T14378L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14378L-2mg2mg£142.00
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TAR-T14378L-5mg5mg£173.00
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TAR-T14378L-10mg10mg£222.00
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TAR-T14378L-1mL1 mL * 10 mM (in DMSO)£291.00
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Further Information

Bioactivity:
AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis.
CAS:
T14378L
Formula:
C60H82N8O10
Molecular Weight:
1075.36
Pathway:
Apoptosis
Purity:
0.9776
SMILES:
C[C@H](NC)C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2[C@H](OCC#CC#CCO[C@@H]3CC4=CC=CC=C4[C@@H]3NC([C@@H]5CCCN5C([C@@H](NC([C@@H](NC)C)=O)C6CCCCC6)=O)=O)CC7=CC=CC=C27)=O)=O)C8CCCCC8)=O.CC(O)=O
Target:
IAP

References

1. Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. 2. Qin Hao, et al. IF-? and Smac mimetics synergize to induce apoptosis of lung cancer cells in a TNF?-independent manner,Cancer Cell Int. 2018; 18: 84.