TargetMol

AZD4320

Product Code:
 
TAR-T14376
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14376-1mg1mg£123.00
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TAR-T14376-2mg2mg£145.00
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TAR-T14376-5mg5mg£185.00
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TAR-T14376-10mg10mg£228.00
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TAR-T14376-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T14376-25mg25mg£383.00
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TAR-T14376-50mg50mg£544.00
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TAR-T14376-100mg100mg£760.00
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Further Information

Bioactivity:
AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively.
CAS:
1357576-48-7
Formula:
C45H48ClF3N4O7S3
Molecular Weight:
945.53
Pathway:
Apoptosis
Purity:
0.9971
SMILES:
CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](O)c1ccccc1-c1ccc(Cl)cc1
Target:
BCL

References

1. Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21.