TargetMol

ALZ-801

Product Code:
 
TAR-T14199
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14199-1mg1mg£101.00
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TAR-T14199-2mg2mg£114.00
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TAR-T14199-5mg5mg£142.00
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TAR-T14199-10mg10mg£195.00
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TAR-T14199-25mg25mg£349.00
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TAR-T14199-50mg50mg£487.00
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TAR-T14199-100mg100mg£672.00
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This product comes from: United States.
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Further Information

Bioactivity:
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, a valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound.
CAS:
1034190-08-3
Formula:
C8H18N2O4S
Molecular Weight:
238.3
Pathway:
Neuroscience
Purity:
0.98
SMILES:
CC(C)[C@H](N)C(=O)NCCCS(O)(=O)=O
Target:
Beta Amyloid

References

1. John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849?861. 2. Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333.