TargetMol

AH 6809

Product Code:
 
TAR-T14148
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14148-2mg2mg£101.00
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TAR-T14148-5mg5mg£119.00
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TAR-T14148-1mL1 mL * 10 mM (in DMSO)£123.00
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TAR-T14148-10mg10mg£141.00
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TAR-T14148-25mg25mg£214.00
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TAR-T14148-50mg50mg£337.00
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TAR-T14148-100mg100mg£499.00
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Further Information

Bioactivity:
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.
CAS:
33458-93-4
Formula:
C17H14O5
Molecular Weight:
298.294
Pathway:
Immunology/Inflammation; GPCR/G Protein
Purity:
0.9759
SMILES:
CC(C)Oc1ccc2c(c1)oc1ccc(cc1c2=O)C(O)=O
Target:
Prostaglandin Receptor

References

1. http://www.millipore.com/publications.nsf/a73664f9f981af8c852569b9005b4eee/cae2c825891fb78e85257b19005fa865/$FILE/HTS099C%20ep1%20datasheet%20121212.pdf 2. Keery RJ, et al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94(3):745-54. 3. Capehart AA, et al. Effects of a putative prostaglandin E2 antagonist, AH6809, on chondrogenesis in serum-free cultures of chick limb mesenchyme. J Cell Physiol. 1991 Jun;147(3):403-11. 4. Piazuelo E, et al. Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma. Curr Cancer Drug Targets. 2012 Feb;12(2):132-43. 5. Rutkai I, et al. Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes. Cardiovasc Res. 2009 Jul 1;83(1):148-54.