TargetMol

Brepocitinib P-Tosylate

Product Code:
 
TAR-T12427
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12427-1mg1mg£95.00
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TAR-T12427-2mg2mg£103.00
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TAR-T12427-5mg5mg£122.00
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TAR-T12427-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T12427-10mg10mg£161.00
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TAR-T12427-25mg25mg£258.00
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TAR-T12427-50mg50mg£439.00
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TAR-T12427-100mg100mg£611.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-06700841 P-Tosylate is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).
CAS:
2140301-96-6
Formula:
C25H29F2N7O4S
Molecular Weight:
561.61
Pathway:
JAK/STAT signaling; Chromatin/Epigenetic; Stem Cells; Angiogenesis
Purity:
0.9982
SMILES:
Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1
Target:
JAK

References

1. Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.