TargetMol

JMV 2959 hydrochloride (925238-89-7 free base)

Product Code:
 
TAR-T11719
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11719-1mg1mg£101.00
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TAR-T11719-2mg2mg£114.00
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TAR-T11719-5mg5mg£142.00
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TAR-T11719-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T11719-10mg10mg£195.00
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TAR-T11719-25mg25mg£343.00
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TAR-T11719-50mg50mg£466.00
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TAR-T11719-100mg100mg£647.00
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Further Information

Bioactivity:
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32?3 nM in LLC-PK1 cells.
CAS:
T11719
Formula:
C30H33ClN6O2
Molecular Weight:
545.08
Pathway:
GPCR/G Protein
Purity:
0.9809
SMILES:
COC1=CC=C(CN2C(CCC3=CC=CC=C3)=NN=C2[C@H](NC(CN)=O)CC4=CNC5=CC=CC=C54)C=C1.Cl
Target:
GHSR

References

1. Moulin A, et al. The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. Amino Acids. 2013 Feb;44(2):301-14. 2. Engel JA, et al. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl). 2015 Dec;232(23):4285-92.