TargetMol

Dooku1

Product Code:
 
TAR-T11076
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11076-1mg1mg£101.00
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TAR-T11076-2mg2mg£114.00
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TAR-T11076-5mg5mg£142.00
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TAR-T11076-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T11076-10mg10mg£185.00
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TAR-T11076-25mg25mg£302.00
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TAR-T11076-50mg50mg£501.00
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TAR-T11076-100mg100mg£691.00
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Further Information

Bioactivity:
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.
CAS:
2253744-54-4
Formula:
C13H9Cl2N3OS
Molecular Weight:
326.2
Purity:
0.994
SMILES:
Clc1cccc(Cl)c1CSc1nnc(o1)-c1ccc[nH]1

References

1. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.