TargetMol

Cl-amidine hydrochloride

Product Code:
 
TAR-T10831L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10831L-5mg5mg£148.00
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TAR-T10831L-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T10831L-10mg10mg£209.00
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TAR-T10831L-25mg25mg£351.00
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TAR-T10831L-50mg50mg£524.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
CAS:
1373232-26-8
Formula:
C14H20Cl2N4O2
Molecular Weight:
347.24
Pathway:
Apoptosis; Chromatin/Epigenetic
Purity:
0.95
SMILES:
Cl.NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1
Target:
Apoptosis; PAD

References

1. Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727?11736. 2. Chumanevich AA, et al. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38. 3. Witalison EE, et al. Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget. 2015 Nov 3;6(34):36053-62. 4. Biron BM, et al., Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model. J Innate Immun. 2017;9(1):22-32.