TargetMol

Elimusertib hydrochloride(1876467-74-1 free base)

Product Code:
 
TAR-T10468
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10468-1mg1mg£111.00
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TAR-T10468-2mg2mg£128.00
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TAR-T10468-5mg5mg£179.00
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TAR-T10468-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T10468-10mg10mg£235.00
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TAR-T10468-25mg25mg£402.00
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TAR-T10468-50mg50mg£563.00
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TAR-T10468-100mg100mg£772.00
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TAR-T10468-500mg500mg£1,500.00
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Further Information

Bioactivity:
Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
CAS:
T10468
Formula:
C20H22ClN7O
Molecular Weight:
411.89
Pathway:
DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
Purity:
0.9986
SMILES:
CN1N=CC=C1C2=CC(N3[C@@H](COCC3)C)=NC4=C(N=CC=C24)C5=CC=NN5.[H]Cl
Target:
ATM/ATR

References

1. Ulrich T. Luecking, et al. Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement. 2. Antje Margret Wengner, et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement 3. Ulrich L?cking, et al. Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models. J Med Chem. 2020 Jul 9;63(13):7293-7325.