TargetMol

A 438079

Product Code:
 
TAR-T10207
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10207-2mg2mg£103.00
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TAR-T10207-5mg5mg£124.00
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TAR-T10207-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T10207-10mg10mg£149.00
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TAR-T10207-25mg25mg£222.00
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TAR-T10207-50mg50mg£322.00
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Quantity:
TAR-T10207-100mg100mg£516.00
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Further Information

Bioactivity:
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
CAS:
899507-36-9
Formula:
C13H9Cl2N5
Molecular Weight:
306.15
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.997
SMILES:
Clc1cccc(-c2nnnn2Cc2cccnc2)c1Cl
Target:
P2X Receptor

References

1. McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28. 2. Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64. 3. Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7. 4. Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.