TargetMol

BAR502

Product Code:
 
TAR-TQ0252
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0252-1mg1mg£156.00
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TAR-TQ0252-5mg5mg£330.00
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TAR-TQ0252-10mg10mg£464.00
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TAR-TQ0252-25mg25mg£699.00
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TAR-TQ0252-50mg50mg£946.00
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TAR-TQ0252-100mg100mg£1,259.00
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Further Information

Bioactivity:
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
CAS:
1612191-86-2
Formula:
C25H40O3
Molecular Weight:
392.62
Pathway:
Metabolism; GPCR/G Protein; Autophagy
Purity:
0.9991
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCO
Target:
FXR; GPCR19; Autophagy

References

Cipriani S, et al. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling. PLoS One. 2015 Jul 15;10(7):e0129866. Festa C, et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands. J Med Chem. 2014 Oct 23;57(20):8477-95. Carino A, et al. BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. Sci Rep. 2017 Feb 16;7:42801.