TargetMol

PMX 53 acetate(219639-75-5 free base)

Product Code:
 
TAR-TP2334
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2334-1mg1mg£222.00
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TAR-TP2334-5mg5mg£416.00
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TAR-TP2334-10mg10mg£581.00
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TAR-TP2334-1mL1 mL * 10 mM (in DMSO)£605.00
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TAR-TP2334-25mg25mg£863.00
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TAR-TP2334-50mg50mg£1,163.00
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TAR-TP2334-100mg100mg£1,540.00
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Further Information

Bioactivity:
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
CAS:
TP2334
Formula:
C49H69N11O9
Molecular Weight:
956.16
Pathway:
Immunology/Inflammation
Purity:
0.9991
SMILES:
N=C(N)NCCC[C@@H]1NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@@H](CC4CCCCC4)NC([C@H]5N(C([C@H](CCCNC1=O)NC([C@H](CC6=CC=CC=C6)NC(C)=O)=O)=O)CCC5)=O)=O)=O.CC(O)=O
Target:
Complement System

References

Subramanian H, et al. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Mol Pharmacol. 2011 Jun;79(6):1005-13. Finch AM, et al. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem. 1999 Jun 3;42(11):1965-74. Ting E, et al. Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain. Br J Pharmacol. 2008 Mar;153(5):1043-53. Holland MC, et al. Synthetic small-molecule complement inhibitors. Curr Opin Investig Drugs. 2004 Nov;5(11):1164-73.