TargetMol

Cyclotraxin B acetate(1203586-72-4 free base)

Product Code:
 
TAR-TP2068L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2068L-1mg1mg£209.00
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TAR-TP2068L-5mg5mg£385.00
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TAR-TP2068L-10mg10mg£544.00
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TAR-TP2068L-25mg25mg£828.00
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TAR-TP2068L-50mg50mg£1,099.00
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TAR-TP2068L-100mg100mg£1,452.00
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Further Information

Bioactivity:
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
CAS:
TP2068L
Formula:
C50H77N13O19S3
Molecular Weight:
1260.42
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9942
SMILES:
C[C@@H](O)[C@H]1C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@H](C(O)=O)CSSC[C@H](N)C(N[C@@H](CC(N)=O)C(N2CCC[C@H]2C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C)O
Target:
Trk receptor

References

Constandil et al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID: Cazorla et al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777 PMID: