TargetMol

M40

Product Code:
 
TAR-TP1992
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1992-1mg1mg£229.00
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Further Information

Bioactivity:
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
CAS:
143896-17-7
Formula:
C94H145N23O24
Molecular Weight:
1981.33
Purity:
0.98
SMILES:
0

References

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874 Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287 Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488