TargetMol

[Phe1ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

Product Code:
 
TAR-TP1988
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TP1988-1mg1mg£262.00
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Further Information

Bioactivity:
Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
CAS:
213130-17-7
Formula:
C61H102N22O14
Molecular Weight:
1367.6
Purity:
0.98
SMILES:
0

References

Okawa et al (1999) Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123 PMID: Guerrini et al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789 PMID: Xu et al (1998) [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127 PMID: Guerrini et al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163 PMID: