TargetMol

ZIP acetate(863987-12-6 free base)

Product Code:
 
TAR-TP1924L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1924L1-1mg1mg£177.00
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Quantity:
TAR-TP1924L1-5mg5mg£313.00
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Quantity:
TAR-TP1924L1-10mg10mg£434.00
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TAR-TP1924L1-25mg25mg£670.00
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Quantity:
TAR-TP1924L1-50mg50mg£914.00
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Quantity:
TAR-TP1924L1-100mg100mg£1,211.00
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Quantity:
TAR-TP1924L1-500mg500mg£2,344.00
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This product comes from: United States.
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Further Information

Bioactivity:
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
CAS:
TP1924L1
Formula:
C92H158N30O19
Molecular Weight:
1988.43
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.9468
SMILES:
0
Target:
PKC

References

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: