TargetMol

FSLLRY-NH2 TFA(245329-02-6 free base)

Product Code:
 
TAR-TP1904L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1904L-1mg1mg£149.00
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Quantity:
TAR-TP1904L-5mg5mg£217.00
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TAR-TP1904L-10mg10mg£293.00
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TAR-TP1904L-25mg25mg£470.00
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TAR-TP1904L-50mg50mg£653.00
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TAR-TP1904L-100mg100mg£863.00
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Quantity:
TAR-TP1904L-500mg500mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
CAS:
TP1904L
Formula:
C41H61F3N10O10
Molecular Weight:
910.99
Pathway:
GPCR/G Protein
Purity:
0.9932
SMILES:
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)N.O=C(O)C(F)(F)F
Target:
Protease-activated Receptor

References

Chen et al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 193 440 PMID: McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID: Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: