TargetMol

Foxy-5 acetate

Product Code:
 
TAR-TP1565L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1565L-1mg1mg£168.00
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TAR-TP1565L-5mg5mg£290.00
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Quantity:
TAR-TP1565L-10mg10mg£389.00
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TAR-TP1565L-25mg25mg£662.00
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Quantity:
TAR-TP1565L-50mg50mg£968.00
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Quantity:
TAR-TP1565L-100mg100mg£1,399.00
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Quantity:
TAR-TP1565L-200mg200mg£2,060.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer cells triggers cytosolic free calcium signaling without affecting β-catenin activation.
CAS:
TP1565L
Formula:
C28H46N6O14S2
Molecular Weight:
754.83
Pathway:
Stem Cells; Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC(C)C[C@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC=O)CCSC)=O)CC(O)=O)=O)=O)CS)=O)CCC(O)=O)=O)C(O)=O.CC(O)=O
Target:
Wnt/beta-catenin

References

Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728. Kelsey R. Prostate cancer: Foxy-5 in prostate cancer model. Nat Rev Urol. 2017 Nov;14(11):638. S?fholm A, et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.