TargetMol

Fz7-21

Product Code:
 
TAR-TP1263
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1263-1mg1mg£177.00
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TAR-TP1263-5mg5mg£313.00
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TAR-TP1263-10mg10mg£434.00
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TAR-TP1263-25mg25mg£670.00
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TAR-TP1263-50mg50mg£914.00
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Quantity:
TAR-TP1263-100mg100mg£1,211.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
CAS:
2247635-23-8
Formula:
C83H114N18O23S2
Molecular Weight:
1796.05
Pathway:
Stem Cells; Cytoskeletal Signaling
Purity:
0.998
SMILES:
CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Target:
Wnt/beta-catenin

References

Nile AH, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.