TargetMol

Angoline

Product Code:
 
TAR-TN6739
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN6739-1mg1mg£122.00
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TAR-TN6739-5mg5mg£189.00
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TAR-TN6739-1mL1 mL * 10 mM (in DMSO)£199.00
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TAR-TN6739-10mg10mg£245.00
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TAR-TN6739-25mg25mg£362.00
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TAR-TN6739-50mg50mg£503.00
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TAR-TN6739-100mg100mg£696.00
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This product comes from: United States.
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Further Information

Bioactivity:
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
CAS:
21080-31-9
Formula:
C22H21NO5
Molecular Weight:
379.412
Pathway:
Stem Cells; JAK/STAT signaling; Immunology/Inflammation
Purity:
0.979
SMILES:
COC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc(OC)c(OC)c12
Target:
IL Receptor; STAT

References

Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.