TargetMol

Bigelovin

Product Code:
 
TAR-TN6735
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN6735-1mg1mg£148.00
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TAR-TN6735-5mg5mg£257.00
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TAR-TN6735-1mL1 mL * 10 mM (in DMSO)£336.00
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TAR-TN6735-10mg10mg£346.00
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TAR-TN6735-25mg25mg£536.00
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TAR-TN6735-50mg50mg£736.00
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Quantity:
TAR-TN6735-100mg100mg£994.00
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This product comes from: United States.
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Further Information

Bioactivity:
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
CAS:
3668-14-2
Formula:
C17H20O5
Molecular Weight:
304.342
Pathway:
Apoptosis; NF-κb; Autophagy; Metabolism; Immunology/Inflammation
Purity:
0.994
SMILES:
C[C@@H]1C[C@@H]2OC(=O)C(=C)[C@H]2[C@H](OC(C)=O)[C@@]2(C)[C@H]1C=CC2=O
Target:
Apoptosis; Reactive Oxygen Species; Retinoid Receptor; Autophagy; RAR/RXR?

References

Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499(2):156-163.