TargetMol

Tetrahydroamentoflavone

Product Code:
 
TAR-TN5130
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN5130-1mg1mg£258.00
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Further Information

Bioactivity:
Tetrahydroamentoflavone is a potent XO inhibitor (IC50 = 92 nM, Ki = 982 nM) with anti-inflammatory effects. Tetrahydroamentoflavone can be used for studies about inflammation and gout.
CAS:
48236-96-0
Formula:
C30H22O10
Molecular Weight:
542.5
Pathway:
Immunology/Inflammation; Neuroscience; Metabolism
Purity:
0.98
SMILES:
Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)c(c2O1)-c1cc(ccc1O)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1
Target:
COX; Xanthine Oxidase

References

Xican Li, et al. Antioxidant Activity and Mechanism of Tetrahydroamentoflavone in vitro. Natural Product Communications, 2013 ,8 (6) :787-9. Selvam C, Jachak SM. A cyclooxygenase (COX) inhibitory biflavonoid from the seeds of Semecarpus anacardium. J Ethnopharmacol. 2004 Dec;95(2-3):209-12. Arimboor R, et al. Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase. J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.