TargetMol

Orobol

Product Code:
 
TAR-TN2019
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2019-1mg1mg£224.00
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Quantity:
TAR-TN2019-2mg2mg£301.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.
CAS:
480-23-9
Formula:
C15H10O6
Molecular Weight:
286.239
Pathway:
Apoptosis; Proteases/Proteasome; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Oc1cc(O)c2c(c1)occ(-c1ccc(O)c(O)c1)c2=O
Target:
BCL; Caspase; PI3K

References

Tomonaga T, et al. Isoflavonoids, genistein, psi-tectorigenin, and orobol, increase cytoplasmic free calcium in isolated rat hepatocytes. Biochem Biophys Res Commun. 1992 Jan 31;182(2):894-9. Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12(9):845. Published 2020 Sep 3. Yang H, et al. Orobol, an Enzyme-Convertible Product of Genistein, exerts Anti-Obesity Effects by Targeting Casein Kinase 1 Epsilon. Sci Rep. 2019 Jun 20;9(1):8942.