TargetMol

Hernandezine

Product Code:
 
TAR-TN1731
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1731-50mg50mgEnquire
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TAR-TN1731-1mg1mg£282.00
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TAR-TN1731-5mg5mg£518.00
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TAR-TN1731-10mg10mg£702.00
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TAR-TN1731-25mg25mg£1,058.00
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Further Information

Bioactivity:
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
CAS:
6681-13-6
Formula:
C39H44N2O7
Molecular Weight:
652.788
Pathway:
Neuroscience; Apoptosis; Membrane transporter/Ion channel; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
COc1ccc2C[C@@H]3N(C)CCc4c(OC)c(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
Target:
TNF; ROS; P-gp; AMPK

References

Hsiao SH, et al. Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1. J Nat Prod. 2016 Aug 26;79(8):2135-42. Ropivia J, et al. Isoquinolines from the roots of Thalictrum flavum L. and their evaluation as antiparasitic compounds. Molecules. 2010 Sep 16;15(9):6476-84.