TargetMol

Eriocalyxin B

Product Code:
 
TAR-TN1620
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1620-1mg1mg£483.00
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TAR-TN1620-1mL1 mL * 10 mM (in DMSO)£871.00
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TAR-TN1620-5mg5mg£871.00
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TAR-TN1620-10mg10mg£1,139.00
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TAR-TN1620-25mg25mg£1,669.00
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TAR-TN1620-50mg50mg£2,231.00
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Quantity:
TAR-TN1620-100mg100mg£2,978.00
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Further Information

Bioactivity:
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells.
CAS:
84745-95-9
Formula:
C20H24O5
Molecular Weight:
344.407
Pathway:
GPCR/G Protein; Apoptosis; JAK/STAT signaling; NF-κb; Stem Cells
Purity:
0.9935
SMILES:
[H][C@@]12CC[C@@H]3C[C@]1(C(=O)C3=C)[C@@]1(O)OC[C@]22C(=O)C=CC(C)(C)[C@@]2([H])[C@@H]1O
Target:
Apoptosis; cAMP; NF-κB; STAT

References

Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2258-63.