TargetMol

Bufarenogin

Product Code:
 
TAR-TN1459
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1459-50mg50mgEnquire
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TAR-TN1459-1mg1mg£128.00
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TAR-TN1459-2mg2mg£148.00
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TAR-TN1459-5mg5mg£222.00
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TAR-TN1459-1mL1 mL * 10 mM (in DMSO)£242.00
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TAR-TN1459-10mg10mg£309.00
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TAR-TN1459-25mg25mg£483.00
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Further Information

Bioactivity:
Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.
CAS:
17008-65-0
Formula:
C24H32O6
Molecular Weight:
416.514
Pathway:
PI3K/Akt/mTOR signaling; MAPK
Purity:
0.9877
SMILES:
[H][C@]12CC[C@]3([H])[C@]([H])(C(=O)[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2
Target:
ERK; MEK; PI3K

References

Perera C?rdova WH, et al. Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na(+)/K(+)-ATPase activity. Toxicon. 2016 Feb;110:27-34. Qinrui Han, et al. Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation. Pharmacol Res Perspect. 2021 Feb;9(1):e00694.