TargetMol

Beta-mangostin

Product Code:
 
TAR-TN1019
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1019-1mg1mg£133.00
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TAR-TN1019-5mg5mg£219.00
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TAR-TN1019-1mL1 mL * 10 mM (in DMSO)£241.00
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TAR-TN1019-10mg10mg£290.00
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TAR-TN1019-25mg25mg£439.00
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TAR-TN1019-50mg50mg£611.00
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Further Information

Bioactivity:
Beta-Mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-Mangostin (β-Mangostin) present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. Beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).
CAS:
20931-37-7
Formula:
C25H28O6
Molecular Weight:
424.493
Pathway:
Microbiology/Virology; Apoptosis
Purity:
0.9801
SMILES:
COc1cc2oc3cc(O)c(OC)c(CC=C(C)C)c3c(=O)c2c(O)c1CC=C(C)C
Target:
Apoptosis; Antibacterial; Parasite

References

Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest. Tumour Biol. 2017 Nov;39(11):1010428317731451. Sunit Suksamrarn, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9. Syam S, et al. ? Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo. J Ethnopharmacol. 2014 Apr 28;153(2):435-45. K Likhitwitayawuid, et al. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998 Feb;64(1):70-2. Chien-Feng Huang, et al.?-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017 Nov;32(11):2360-2370.