TargetMol

Kukoamine A

Product Code:
 
TAR-TN1016
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN1016-50mg50mgEnquire
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TAR-TN1016-1mg1mg£169.00
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TAR-TN1016-5mg5mg£372.00
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TAR-TN1016-1mL1 mL * 10 mM (in DMSO)£402.00
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TAR-TN1016-10mg10mg£518.00
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TAR-TN1016-25mg25mg£779.00
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Further Information

Bioactivity:
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
CAS:
75288-96-9
Formula:
C28H42N4O6
Molecular Weight:
530.666
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κb; Microbiology/Virology; Metabolism
Purity:
0.9745
SMILES:
Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O
Target:
NF-κB; Lipoxygenase; DNA/RNA Synthesis; Parasite

References

Hadjipavlou-Litina D, et al. Kukoamine A analogs with lipoxygenase inhibitory activity. J Enzyme Inhib Med Chem. 2009 Oct;24(5):1188-93. Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.