TargetMol

Cerevisterol

Product Code:
 
TAR-TMA0984
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TMA0984-1mg1mg£189.00
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Further Information

Bioactivity:
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. Cerevisterol acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-κB, AP-1, and Nrf2-mediated HO-1 signaling cascade.
CAS:
516-37-0
Formula:
C28H46O3
Molecular Weight:
430.66
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@H](C3)O)[C@@]33O)[C@@H]1C2=C[C@H]3O
Target:
DNA/RNA Synthesis

References

Mizushina Y, et al. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg Med Chem. 1999 Sep;7(9):2047-52. Alam MB, et al. Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-?B/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade. Biomolecules. 2020 Jan 29;10(2):199. Koolen HH, et al. An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera. Nat Prod Res. 2012 Nov;26(21):2013-9.