TargetMol

MIDD0301

Product Code:
 
TAR-T9946
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9946-1mg1mg£227.00
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TAR-T9946-5mg5mg£422.00
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TAR-T9946-10mg10mg£597.00
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TAR-T9946-25mg25mg£1,017.00
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TAR-T9946-50mg50mg£1,491.00
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TAR-T9946-100mg100mg£2,201.00
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Quantity:
TAR-T9946-200mg200mg£3,266.00
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This product comes from: United States.
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Further Information

Bioactivity:
MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.
CAS:
2187489-08-1
Formula:
C19H13BrFN3O2
Molecular Weight:
414.23
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
C[C@H]1N=C(c(cccc2)c2F)c(cc(cc2)Br)c2-n2c1c(C(O)=O)nc2
Target:
GABA Receptor

References

Nicolas M Zahn, et al. MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA A receptors without causing systemic immune suppression. Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):75-84. Gene T Yocum, et al. A novel GABA A receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L385-L390.