TargetMol

YM-244769

Product Code:
 
TAR-T9888
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
YM-244769 is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys.
CAS:
838819-70-8
Formula:
C26H22FN3O3
Molecular Weight:
443.477
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.98
SMILES:
O=C(NCC1=CC=CC(N)=C1)C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2
Target:
Calcium Channel

References

Takahiro Iwamoto, et al. YM-244769, a Novel Na + /Ca 2+ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects Against hypoxia/reoxygenation-induced SH-SY5Y Neuronal Cell Damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.