TargetMol

LOXO-195

Product Code:
 
TAR-T9496
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9496-50mg50mgEnquire
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Quantity:
TAR-T9496-1mg1mg£98.00
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TAR-T9496-2mg2mg£109.00
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TAR-T9496-5mg5mg£135.00
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TAR-T9496-10mg10mg£168.00
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Quantity:
TAR-T9496-25mg25mg£262.00
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This product comes from: United States.
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Further Information

Bioactivity:
(6RS)-LOXO-195 is a potent and selective Trk tyrosine kinase inhibitor.
CAS:
1350884-56-8
Formula:
C20H21FN6O
Molecular Weight:
380.427
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9792
SMILES:
[H][C@]12CCCN1c1ccn3ncc(C(=O)NC(C)CCc4ncc(F)cc24)c3n1
Target:
Trk receptor

References

Emiliano Cocco, et al. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol. 2018 Dec;15(12):731-747. Wang S, Li K, Pickholz E, et al.An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis.Science Translational Medicine.2023, 15(677): eadd3949.