TargetMol

HM43239

Product Code:
 
TAR-T9428
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9428-1mg1mg£205.00
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TAR-T9428-5mg5mg£407.00
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TAR-T9428-1mL1 mL * 10 mM (in DMSO)£470.00
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TAR-T9428-10mg10mg£573.00
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TAR-T9428-25mg25mg£871.00
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TAR-T9428-50mg50mg£1,139.00
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TAR-T9428-100mg100mg£1,508.00
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Further Information

Bioactivity:
HM43239 is a selective FLT3 inhibitor (IC50s: 1.1 nM for FLT3 WT, 1.8 nM for FLT3 ITD, and 1.0 nM for FLT3 D835Y kinases, respectively).
CAS:
2569527-64-4
Formula:
C29H33ClN6
Molecular Weight:
501.07
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9907
SMILES:
CC1=CC2=C(C(C3=NC(NC4=CC(CN5C[C@H](N[C@H](C5)C)C)=CC(C6CC6)=C4)=NC=C3Cl)=CN2)C=C1
Target:
FLT

References

Miyoung Lee, et al. Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia. Cancer Res July 1 2018 (78) (13 Supplement) 804. Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020 Jul;374(1):113-125. Huang F, Liang J, Lin Y, et al.Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis.Communications Biology.2023, 6(1): 972.