TargetMol

WAY-169916

Product Code:
 
TAR-T8981
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8981-1mg1mg£103.00
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TAR-T8981-5mg5mg£148.00
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TAR-T8981-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T8981-10mg10mg£201.00
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TAR-T8981-25mg25mg£349.00
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TAR-T8981-50mg50mg£535.00
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TAR-T8981-100mg100mg£740.00
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Quantity:
TAR-T8981-500mg500mg£1,428.00
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This product comes from: United States.
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Further Information

Bioactivity:
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.
CAS:
669764-18-5
Formula:
C17H13F3N2O2
Molecular Weight:
334.298
Pathway:
NF-κb
Purity:
0.9844
SMILES:
Oc1ccc(-c2nn(CC=C)c3c(cccc23)C(F)(F)F)c(O)c1
Target:
NF-κB

References

Murray IA, Krishnegowda G, DiNatale BC, Flaveny C, Chiaro C, Lin JM, Sharma AK, Amin S, Perdew GH. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17;23(5):955-66. doi: 10.1021/tx100045h. PubMed PMID: 20423157; PubMed Central PMCID: PMC2871980. Liu Z, Wang L, Tan H, Zhou S, Fu T, Xia Y, Zhang Y, Wang J. Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds. Chem Commun (Camb). 2014 May 21;50(39):5061-3. doi: 10.1039/c4cc00962b. Epub 2014 Apr 9. PubMed PMID: 24714999. Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol. 2010 Nov;6(11):837-43. doi: 10.1038/nchembio.451. Epub 2010 Oct 10. PubMed PMID: 20924370; PubMed Central PMCID: PMC2974172. Gao L, Tu Y, ?gren H, Eriksson LA. Characterization of agonist binding to His524 in the estrogen receptor ? ligand binding domain. J Phys Chem B. 2012 Apr 26;116(16):4823-30. doi: 10.1021/jp300895g. Epub 2012 Apr 17. PubMed PMID: 22482773.