TargetMol

Danicopan

Product Code:
 
TAR-T8509
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8509-1mg1mg£148.00
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TAR-T8509-2mg2mg£181.00
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TAR-T8509-5mg5mg£252.00
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TAR-T8509-1mL1 mL * 10 mM (in DMSO)£303.00
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TAR-T8509-10mg10mg£348.00
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TAR-T8509-25mg25mg£541.00
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TAR-T8509-50mg50mg£744.00
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TAR-T8509-100mg100mg£1,002.00
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Further Information

Bioactivity:
Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
CAS:
1903768-17-1
Formula:
C26H23BrFN7O3
Molecular Weight:
580.418
Pathway:
Immunology/Inflammation
Purity:
0.9988
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(C)nc1
Target:
Complement System

References

Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.