TargetMol

SIB-1757

Product Code:
 
TAR-T8434
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8434-1mg1mg£131.00
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TAR-T8434-2mg2mg£149.00
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TAR-T8434-5mg5mg£193.00
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TAR-T8434-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T8434-10mg10mg£257.00
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TAR-T8434-25mg25mg£406.00
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TAR-T8434-50mg50mg£568.00
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TAR-T8434-100mg100mg£777.00
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Quantity:
TAR-T8434-500mg500mg£1,508.00
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Further Information

Bioactivity:
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
CAS:
31993-01-8
Formula:
C12H11N3O
Molecular Weight:
213.24
Pathway:
Neuroscience
Purity:
0.9849
SMILES:
Cc1ccc(O)c(N=Nc2ccccc2)n1
Target:
GluR

References

Varney M A A , Cosford N D P , Jachec C , et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 290(1):170-181. Dogrul A , Ossipov M H , Lai J , et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats[J]. 2000, 292(2):0-118.