TargetMol

JCN037

Product Code:
 
TAR-T8431
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8431-1mg1mg£109.00
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TAR-T8431-5mg5mg£189.00
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TAR-T8431-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T8431-10mg10mg£254.00
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TAR-T8431-25mg25mg£377.00
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TAR-T8431-50mg50mg£527.00
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TAR-T8431-100mg100mg£725.00
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This product comes from: United States.
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Further Information

Bioactivity:
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRv? with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
CAS:
2305154-31-6
Formula:
C16H11BrFN3O2
Molecular Weight:
376.185
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
1
SMILES:
Fc1c(Br)cccc1Nc1ncnc2cc3OCCOc3cc12
Target:
EGFR

References

Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.