TargetMol

TED-347

Product Code:
 
TAR-T8421
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8421-1mg1mg£142.00
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TAR-T8421-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T8421-5mg5mg£164.00
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TAR-T8421-10mg10mg£229.00
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TAR-T8421-25mg25mg£389.00
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TAR-T8421-50mg50mg£550.00
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TAR-T8421-100mg100mg£768.00
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Further Information

Bioactivity:
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
CAS:
2378626-29-8
Formula:
C15H11ClF3NO
Molecular Weight:
313.7
Pathway:
Stem Cells
Purity:
0.9991
SMILES:
FC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
Target:
YAP

References

Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.