TargetMol

ML188

Product Code:
 
TAR-T8371
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8371-1mg1mg£130.00
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TAR-T8371-2mg2mg£157.00
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TAR-T8371-5mg5mg£213.00
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TAR-T8371-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T8371-10mg10mg£303.00
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TAR-T8371-25mg25mg£546.00
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TAR-T8371-50mg50mg£838.00
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TAR-T8371-100mg100mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
CAS:
1417700-13-0
Formula:
C26H31N3O3
Molecular Weight:
433.552
Pathway:
Microbiology/Virology
Purity:
0.9804
SMILES:
CC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1
Target:
Virus Protease; SARS-CoV

References

Jacobs J , Grum-Tokars V , Zhou Y , et al. Discovery, Synthesis, And Structure-Based Optimization of a Series of?N?-(?tert?-Butyl)-2-(?N?-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease[J]. Journal of Medicinal Chemistry, 2013, 56(2):534-546. Michael Berry, Burtram Fielding , Junaid Gamieldien.Human Coronavirus OC43 3CL Protease and the Potential of ML188 as a Broad-Spectrum Lead Compound: Homology Modelling and Molecular Dynamic Studies[J].BMC Struct Biol. 2015 Apr 28;15:8.