TargetMol

FPL 62064

Product Code:
 
TAR-T8356
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8356-1mg1mg£115.00
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TAR-T8356-5mg5mg£168.00
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TAR-T8356-1mL1 mL * 10 mM (in DMSO)£206.00
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TAR-T8356-10mg10mg£229.00
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TAR-T8356-25mg25mg£413.00
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TAR-T8356-50mg50mg£591.00
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TAR-T8356-100mg100mg£812.00
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Further Information

Bioactivity:
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).
CAS:
103141-09-9
Formula:
C16H15N3O
Molecular Weight:
265.316
Pathway:
Immunology/Inflammation; Metabolism; Neuroscience
Purity:
0.9964
SMILES:
COc1ccc(Nc2ccn(n2)-c2ccccc2)cc1
Target:
Lipoxygenase; COX

References

Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42.