TargetMol

trifarotene

Product Code:
 
TAR-T7586
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7586-1mg1mg£95.00
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TAR-T7586-2mg2mg£106.00
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TAR-T7586-5mg5mg£128.00
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TAR-T7586-1mL1 mL * 10 mM (in DMSO)£129.00
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TAR-T7586-10mg10mg£168.00
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TAR-T7586-25mg25mg£229.00
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TAR-T7586-50mg50mg£369.00
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TAR-T7586-100mg100mg£517.00
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Further Information

Bioactivity:
trifarotene is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).
CAS:
895542-09-3
Formula:
C29H33NO4
Molecular Weight:
459.586
Pathway:
Metabolism; Autophagy
Purity:
0.9978
SMILES:
CC(C)(C)c1cc(ccc1N1CCCC1)-c1cc(ccc1OCCO)-c1ccc(cc1)C(O)=O
Target:
Retinoid Receptor; Autophagy

References

J Aubert, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-? agonist trifarotene. Br J Dermatol. 2018 Aug;179(2):442-456. Etienne Thoreau, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741.