TargetMol

Upadacitinib

Product Code:
 
TAR-T7503
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7503-1mg1mg£102.00
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TAR-T7503-1mL1 mL * 10 mM (in DMSO)£103.00
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TAR-T7503-2mg2mg£115.00
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TAR-T7503-5mg5mg£144.00
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TAR-T7503-10mg10mg£177.00
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TAR-T7503-25mg25mg£257.00
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TAR-T7503-50mg50mg£331.00
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TAR-T7503-100mg100mg£438.00
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TAR-T7503-200mg200mg£630.00
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TAR-T7503-500mg500mg£1,066.00
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This product comes from: United States.
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Further Information

Bioactivity:
Upadacitinib (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
CAS:
1310726-60-3
Formula:
C17H19F3N6O
Molecular Weight:
380.375
Pathway:
JAK/STAT signaling; Stem Cells; Chromatin/Epigenetic; Angiogenesis
Purity:
0.9989
SMILES:
CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F
Target:
JAK

References

Nakayamada S, et al. Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis. BioDrugs. 2016 Oct;30(5):407-419. Kremer JM, et al. A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy. Arthritis Rheumatol. 2016Dec;68(12):2867-2877. Si H, Wang J, He R, et al. Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor. Frontiers in oncology. 2021, 11: 807200-807200. Wang F, Wang S, Zhang C, et al.Noncanonical JAK1/STAT3 interactions with TGF-? modulate myofibroblast transdifferentiation and fibrosis.American Journal of Physiology-Lung Cellular and Molecular Physiology.2022, 323(6): L698-L714.